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KMID : 1007520220310010121
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Food Science and Biotechnology
2022 Volume.31 No. 1 p.121 ~ p.129
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Antioxidant and lipid-reducing effects of Rosa rugosa root extract in 3T3-L1 cell
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Choi Da-Hye
Han Joon-Hee
Hong Min
Lee Sun-Yeop
Lee Soo-Ung
Kwon Tae-Hyung
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Abstract
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Rosa rugosa root is traditionally known to be effective in the treatment of diabetes in Korea. R. rugosa root-specific compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clarified. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of R. rugosa (REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (PPARγ), CCAAT/enhancer binding protein alpha (C/EBPα), and sterol regulatory element binding protein1 (SREBP1c) and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.
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KEYWORD
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Lipid-reducing, Antioxidant, Adipogenesis, Lipogenesis, Rosa rugosa
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